"Our hearts go out to the parents and family members who lost loved ones," the district said in a release. "We are all feeling the overwhelming grief of this horrific event."
The district said mental health support and school nurses will be available throughout the district for students, staff and faculty.
A family assistance center is open on Saturday from 9 a.m. to 6 p.m. at Aldersgate United Methodist Church.
Mental health professionals will also be available 24 hours a day through a toll-free crisis hotline number- 1-800-595-0869.
All campuses in Santa Fe ISD will be closed on Monday, May 21 and Tuesday, May 22. The district will update students and parents as soon as a plan for returning to school is finalized.
The district attached a document entitled "Talking to Children about the Shooting" to help provide parents with ideas on how to talk to their children about their feelings surrounding the incident.