Deputies said the two men were driving down Etheline Street near Homestead when someone in another car shot them both around 12:30 a.m. Saturday.
One of the men was shot in the mouth.
"The report was it was car to car, " said Captain John Shannon with the Harris County Sheriff's Office. "We don't have a description of it."
Deputies said they do not have a description of the shooter.
Both men are in stable condition and are recovering at the hospital.