The freeway finally reopened around 8:30 a.m.
The Harris County Sheriff's Office says the pursuit started off Thompson and Jones, where a deputy tried to pull over the suspect driving an Impala 42 mph in a 30 mph zone.
[Ads /]
The driver never stopped, speeding off to I-10 where he started to go the wrong way. He hit speeds of 103 mph as he went westbound in the eastbound lanes.
The deputy tried to keep up with him as he led them on a chase that lasted about 30 minutes.
By the time officials caught up to the suspect, he had already crashed into a barrier, causing his vehicle to burst into flames.
Authorities believe the vehicle went airborne as it hit the barrier, slamming into an 18-wheeler that ended up going off the side of the road.
The suspect was killed. The driver of the big rig was taken to the hospital for minor injuries.
[Ads /]
Officials say the suspect's vehicle and part of the license plate also appears to match that of a vehicle involved in a chase in Baytown on Sunday.
Live traffic map
Follow Katherine Marchand on Facebook and Twitter.