The crash was first reported on Houston Transtar at about 3:15 a.m., but officials say the wreck happened earlier than that at about 2:40 a.m.
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A view from SkyEye showed the driver's 2020 Toyota RAV4 loaded onto a flatbed trailer. The front side of the vehicle was crushed and the airbags had been deployed.
Police say the woman was on the wrong side of the road when she hit a 2007 Freightliner with semi-trailer head-on.
The woman was flown to Memorial Hermann Hospital. ABC13 is working to get an update on her condition.
The driver of the Freightliner was checked out and cleared by Baytown paramedics.
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The mainlanes of the freeway were shut down after the crash, bringing traffic to a halt for seven hours.
The freeway reopened at roughly 10:15 a.m. after hazmat crews cleaned up the oil spill.
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