Deputies responded to the 2400 block of Heather Street at about 4:15 a.m., where a 46-year-old man was found with stab wounds on his back.
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Responding deputies performed CPR on the man until he was air lifted to Memorial Hermann Hospital in the medical center, where he was pronounced dead.
The man's 35-year-old girlfriend stayed at the scene and cooperated with investigators.
Detectives said the couple was fighting with each other physically when the woman stabbed the man several times.
The woman was also transported to the hospital to be treated for her injures from the fight.
Neighbors told investigators that they were woken up by the woman pleading for help before they discovered she stabbed her boyfriend.
The case will be presented to a Harris County Grand Jury disposition.
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If you need help getting out of a domestic violence situation, call the Houston Area Women's Center 24/7 hotline at 713-528-2121 or call AVDA at 713-224-9911. You can also click here to chat with an advocate online. If you are deaf or hard of hearing and need help, call 713-528-3625.