The Harris County Sheriff's Office Vehicular Crimes Division said drivers should avoid the intersection of Aldine Mail Route Road and Henry Road.
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It's unclear what led up to the deadly crash or who died, though SkyEye flew over the scene, where a body was seen covered with a sheet near the motorcycle. A pickup truck was also seen stopped in the intersection.
Henry Road is closed and eastbound traffic is being diverted through a parking lot.
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"Please pray for those involved as well as their families," the division said in a post on X, formerly Twitter.