According to investigators, a pedestrian was either standing in or crossing SH-249 when he was struck by a Jeep around 3 a.m.
Deputies responding to the scene found the man dead upon arrival.
SH-249 was closed in both directions from West Road to Northwest Park Drive for a couple hours.
All lanes of the highway have since reopened.
The driver who hit the man stayed at the scene, cooperated with the investigation and did not show any signs of impairment, according to investigators.
Investigators had not released the identity or age of the man who was hit and killed.