It happened in the 5000 block of Louetta Road around 10 p.m. Saturday.
The Harris County Sheriff's Office says Luke Ford was driving a gray Infiniti on Louetta near Kuykendahl when he veered into oncoming traffic and slammed into a Ford F-150 with two people inside.
All four people were taken to the hospital where Ford's brother, Zachary, later died.
According to a tweet posted by Sheriff Ed Gonzalez, investigators believe the brothers were heading home after working for a rideshare food delivery service.
The incident remains under investigation by the Harris County Sheriff's Office Vehicular Crimes Division. Investigators say no charges have been filed.