It happened around 7:30 a.m. in the 1100 block of Pasadena Boulevard near Southmore Avenue.
Pasadena firefighters worked to douse the flames that consumed the roof of the structure.
The brick two-story structure is located in the central part of the city next to a small shopping center.
It wasn't immediately clear how the fire started. No one was was inside when it broke out, according to the Pasadena Fire Department.
The structure was a total loss.