During his opening monologue, wearing a red, Chicago Teachers Union sweatshirt, the rapper sent messages of support to the striking teachers.
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"To the teachers in Chicago, I know you guys are on strike right now, I just want you to know I fully support you," the rapper said.
He also created some very funny raps about the city's nickname. Watch the video above to see more.
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Chance first hosted the late-night comedy show back in 2017.