The Harris County Sheriff's Office said that at about 11 p.m., deputies were trying to stop a driver racing along Sam Houston Parkway.
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This led to a 12 mile-chase that lasted 10 minutes, according to deputies.
The driver allegedly lost control on Foy Lane, near Hopper, and crashed into the mobile home.
Video at the scene shows crews trying to pull the car out of the home.
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HCSO said three people inside the car were taken to the hospital, including a passenger with serious injuries.
A woman, who lives in the mobile home, was also taken to the hospital in fair condition, HCSO said.
SEE ALSO: Chase ends when HPD cruiser and suspect vehicle slam into neighboring homes in Houston's eastside
HPD cruiser, suspect vehicle slam into neighboring houses during chase