The accident happened Monday afternoon north of Hockley, on FM 2920 near Hegar Road.
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Harris County Sheriff Ed Gonzalez said the commercial truck was hauling five cars at the time. The driver veered to the left, striking an SUV and going off the roadway.
Three of the vehicles on the car mover shifted, causing the truck to land on its side. The front cab also rolled.
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The truck driver died at the scene.
Life Flight was called to the scene of the accident. No details of any other injuries are available.