It happened shortly before 5:30 p.m. Monday in the 1500 block of Brittmoore Road.
The boy was in a four-door sedan, according to investigators. Police told Eyewitness News he ran a stop sign at an intersection and was hit by the 18-wheeler.
Another innocent driver was involved, but there's no word on that driver's condition.
The crash caused a fuel spill, so cleaning crews were seen in the area attempting to clear the scene.
In addition, the 18-wheeler also hit a power pole, causing a power outage in the area.
The incident remains under investigation.
UPDATE: HPD initially released information that the person killed in the crash was a woman. Police later confirmed it was a 17-year-old boy.