The team was on the way to Houston, where they'll face off against the Houston Astros Friday night, when their plane was diverted to Detroit because of mechanical issues.
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Boston had just finished up their series in Toronto against the Blue Jays.
The team was given a new plane and landed at Hobby Airport just after 12 a.m.
The Red Sox and Astros face off in a three-game series, with game one starting at 7:10 p.m.
Pitcher Wade Miley will take the mound for the Astros, while Chris Sale will be on the bump for Boston.
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The teams last faced each other May 17 for a three-game series on Boston's home turf. The Astros took that series 2-1.
Now Houston is hoping for a sweep just one week later at Minute Maid Park.
The Astros are 18-6 on their home turf. Houston has hit 90 combined home runs this season, most in the American League. George Springer leads the team with 17, averaging one every 10.7 at-bats.
The Associated Press contributed to this report.