Some 1,500 guests filled the church to pay their respects and say their final farewells to Mrs. Bush.
Hundreds of mourners were spotted standing along Memorial Drive and on the I-10 bridge, as the motorcade departed Houston to the Bush Library at Texas A&M University.
The former First Lady will be buried in a gated plot where her 3-year-old daughter, Robin, who died of leukemia in 1953, is buried.