El Paso police say 42-year-old Jennifer Carmony is the suspect in their disappearances.
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The Texas Department of Public Safety released an image of Carmony, described as a white woman with blonde hair and blue eyes and 5 feet 5 inches tall.
Police say they may be in a red 2004 F-150 with Texas license plate BE88718 and were last seen Friday in the 5300 block of Woodrow Bean at about 6 p.m.
The truck may be spray-painted black, authorities said.
Texas DPS released the following description of the children, who are between 4 and 16 years old:
- Michael Carmony: 4-year-old boy, white, blond, black eyes, standing at 3 feet 4 inches, weighing 35 pounds
- Audrit Williams: 12-year-old boy, white, blond, black eyes, 5 feet 8 inches tall, weighing 130 pounds
- Isabella Williams: 14-year-old girl, white, blonde, brown eyes, 5 feet 4 inches tall, weighing 110 pounds
- Aidan Williams: 16-year-old boy, white, black eyes, 5 feet 8 inches tall, weighing 110 pounds
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The relationship between Carmony and the children and the circumstances surrounding their disappearance are unclear.
If you have any information, contact the El Paso Police Department at (915) 212-4040.