Michelle Reynolds, 48, is a sixth grade Reading and Language Arts teacher at Fairview Junior High in Alvin and was reported missing by her husband.
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The Brazoria County Sheriff's Office said Reynolds was last seen driving the located car - a Lexus RX 300 with Texas license plate number RSV-2914.
Deputies said no known contact has been made with family or friends since she was reported missing.
BCSO said it is coordinating with the New Orleans Police Department in this investigation.
ABC13 reached out to Alvin ISD, which sent the following statement:
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The safety and security of our students and staff is of utmost importance to Alvin ISD. We were made aware that one of our employees, Michelle Reynolds, has not been heard from since Thursday afternoon. Alvin ISD has reached out to the Reynolds family and has been assisting the family during this difficult time.
If you have any information on Mrs. Reynolds' whereabouts, please contact the Brazoria County Sheriff's Office at 979-864-2392 in reference to case # 2209-0540.