Alexandra Pineda, 18, was reported missing at 1 p.m. Thursday. She was last seen by her family in the 4700 block of Baker Road in Needville, deputies said.
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Officials believe Pineda's last known location was with her ex-boyfriend, 19-year-old Dylan Gonzalez, in the 500 block of Tegner Street in El Campo, Texas at 2:45 p.m.
A weapons investigation by the El Campo Police Department was being conducted when Pineda and Gonzalez both fled on foot, officials said.
They believe Gonzalez is possibly armed.
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Pineda is 5'1". There are reports that she was last seen in two different outfits, including blue pajama pants with polar bears and a black jacket, or a yellow shirt and gray sweat pants.
Deputies released photos of both Pineda and Gonzalez.
You're urged to call Sgt. A. Hickey with the Criminal Investigations Division at 281-341-4686 if you have any information on Pineda's whereabouts.