SkyEye 13 was over the scene at North Sam Houston Tollway and the Antoine feeder road westbound.
The bus didn't appear to have visible damage, but students were on the bus at the time.
Video shows them being led off the bus.
While over the area in SkyEye, helicopter reporter Tammy Rose spotted a car with front-end damage.
It's unclear what caused the crash or if there were any injuries.