Officials said that deputies responded to where the Cessna 172H crashed near Beaumont Highway and Adlong Johnson Road.
According to officials, the plane failed at takeoff, then crashed into a train at the railyard.
The passenger and pilot aboard the plane were taken to hospital via Life Flight and the other by ambulance, HCSO says.
Their status is unclear at this time, officials said.
According to documents, the plane is registered to someone in the Katy area and was coming in from the Baytown area.