Officials said that deputies responded to where the Cessna 172H crashed near Beaumont Highway and Adlong Johnson Road.
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According to officials, the plane failed at takeoff, then crashed into a train at the railyard.
The passenger and pilot aboard the plane were taken to hospital via Life Flight and the other by ambulance, HCSO says.
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Their status is unclear at this time, officials said.
According to documents, the plane is registered to someone in the Katy area and was coming in from the Baytown area.