Houston police released surveillance video of the January 4 robbery in an attempt to identify the suspects.
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Police say the men entered the Hampton Inn and Suites on the Sam Houston Parkway just after 8 p.m.
On the video the men were seen carrying guns and walking around the lobby.
Once they located an employee they demanded cash from the drawer and the safe.
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When the employee couldn't access the safe, the suspects threw the money from the drawer into a trash bag and ran.
The suspects are described as black males between 20 and 30 years old.
Anyone who recognizes the men is urged to call the police.