The Harris County Sheriff's Office said deputies are looking into whether the shooting was tied to a shoplifting case at a 99 Cents Only Store.
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Earlier on Saturday, a woman was working in the store when there was a disturbance involving shoplifters, according to the sheriff's office.
Later, deputies said the employee and her family were driving on Little York near the Eastex Freeway at about 10 p.m. when shots were fired.
A male relative exited the vehicle at some point and was shot in the chest, according to Sgt. Jonathan Ryan.
Ryan said the shoplifters were the same people who opened fire, but deputies aren't yet sure whether the theft was the motive behind the shooting.
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The man was taken to the hospital to undergo surgery, and the shooters haven't been caught, according to deputies.
A child was also in the pickup but wasn't hurt.