Around 2 a.m., deputies got a call to the Haverstock Hills apartments on Aldine Bender near Lee.
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Deputies say the mother called after her son got a gun and somehow, it went off and his 5-year-old sister was shot.
"Caller advises son was playing with gun and shot younger sister in the upper leg," a 911 dispatcher could be heard saying in Rangecast audio. "Advised not to touch the weapon. The weapon is still supposed to be on the bed."
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The girl was hit in the leg and taken to Memorial Hermann Hospital. She is expected to survive.
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Harris County sheriff's deputies say there were four people in the home at the time of the shooting: the 5-year-old girl, her brother who allegedly shot her, another older brother and the children's mother.
ABC13 reporter TJ Parker is asking deputies where the 6-or-7-year-old brother got the gun and who the gun belongs to.
Follow TJ Parker on Facebook, Twitter and Instagram.