It happened around 8 p.m. on Highway 249 near the Greens Road exit ramp.
A man in a white car was traveling along 249 and pulled in front of a white van before hitting the brakes, according to investigators. The van's driver couldn't avoid the car and slammed into it.
The car's driver later died at a hospital.
Investigators were not sure why the driver attempted to stop suddenly before the crash, but said they do not believe alcohol was a factor.