The Houston Police Department said the incident happened Saturday at about 12:30 a.m. at an apartment home on Dunlap near Bellaire Boulevard.
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Police said relatives were upset that their 18-year-old family member had a pistol because he was not being safe with it.
His brother tried to take the gun away, but the man didn't let go, according to police.
"(It wasn't) a full-fledged fight, but (there was) a struggle for the gun. It went off and shot the 18-year-old," Lt. R. Willkens said.
According to investigators, people nearby said there were four people, who were all young adults, inside the Sharpstown area apartment, including the man who was killed.
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The 18-year-old's brother, cousin, and another woman are speaking with police.
Law enforcement hasn't said whether charges will be filed.