At about 3:25 p.m., Houston police officers responded to the crash at 10009 Highway 225.
The video above is ABC13 Houston's 24/7 livestream.
In a tweet, police wrote that units are shutting down the outbound lanes as they clean up.
SkyEye video shows the big rig turned over as crews work to get this cleared on IH-610 East Loop southbound.
Houston TranStar says the one-vehicle accident is also a spill. It is unclear what exactly led to the crash.