At about 3:25 p.m., Houston police officers responded to the crash at 10009 Highway 225.
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The video above is ABC13 Houston's 24/7 livestream.
In a tweet, police wrote that units are shutting down the outbound lanes as they clean up.
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SkyEye video shows the big rig turned over as crews work to get this cleared on IH-610 East Loop southbound.
Houston TranStar says the one-vehicle accident is also a spill. It is unclear what exactly led to the crash.