Sheriff Ed Gonzalez said his deputies responded to a major crash in the 11400 block of Crosby-Lynchburg Road and Floyd.
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Gonzalez said in a post on X, formerly Twitter, that the wreck was between an 18-wheeler and a sedan. One person is dead at the scene.
SkyEye flew over the aftermath, which showed first responders still there at the crash.
It wasn't immediately known who was killed.
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The road is shut down in both directions.
If this is your route, you'll want to find an alternate for now. Traffic is being diverted back to I-10 and Highway 90.