While there were no major injuries reported, Texas Department of Transportation said cleanup of the incident caused closures of up to four hours, which hindered the drive home in points like southwest Houston, Missouri City and Sugar Land.
The delay was made a little bit worse because of the hazmat nature of the cleanup. Officials disclosed the load contained raw sewage.
TxDOT urged motorists to look for alternate routes and to refer to Houston TranStar for updates.
Do you hate Houston traffic as much as we do? Join the club!
SEE ALSO: This major freeway roadwork will slow down your weekend plans