Harris County Sheriff's Office said the crash happened just before 4:30 p.m.
Authorities are not sure how many vehicles were involved.
Two men died in the crash, according to the sheriff's office.
The closure stretched from Highway 90 to Woodforest.
UPDATE: Two men are confirmed deceased from this evening’s crash on Beltway 8 near Wallisville Rd. Investigators remain on the scene. #HouNews— HCSOTexas (@HCSOTexas) December 8, 2018
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