Troopers say the crash happened on northbound Interstate 45 near Corsicana at around 9 p.m. Wednesday.
A Ford Explorer was traveling the wrong way when it slammed into the front of a Nissan Rogue. The crash caused a Toyota Avalon to rear-end the Nissan.
All three people inside the Nissan died as a result of the wreck. Two people in the Ford and the Toyota driver were taken to a hospital with serious injuries.
Authorities also say the wreck caused a separate two-vehicle crash when another SUV tried to avoid the crash. There were no injuries reported.
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