The three-alarm fire broke out on West 59th Street near Tenth Avenue just after 5 p.m.
A total of 13 people were hurt in the fire, three of them seriously. The three FDNY firefighters suffered non-life threatening injuries.
This video from Eyewitness News viewer Harold Abrams shows flames shooting out of the apartment:
And this video shows the flames from up above, via Brian Santoro:
Fire officials said the fire started in a third-floor apartment.
FDNY trucks lined the streets surrounding the building and officers shut down traffic in the area.