Authorities have had the highway closed off between CR 310 and FM 2611 since 6:50 a.m., around the time the crash happened.
We're told that a vehicle was traveling southbound when it veered into the northbound lanes of traffic, causing the collision.
Three of the vehicles wound up several feet from the road.
Two people were taken to the hospital as a precaution.
State troopers are investigating what caused the driver traveling southbound to leave the lane.
There's no word how long it will take for the road to reopen.
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