It happened as the silver pickup truck tried to get onto Highway 90 westbound near Uvalde. According to the Harris County Sheriff's Office, the vehicle somehow lost control and flipped more than six times, landing on the feeder road.
Five teens -- three males and two females -- were inside the truck.
Authorities say a 17-year-old male passenger in the back seat wasn't wearing his seat belt and was thrown from the truck. He was transported via Life Flight in critical condition. We're told he is now on life-support and isn't expected to make it.
The four other teens, all younger than 17, also were transported to area hospitals. We don't have details on their conditions.
Detectives are still trying to determine whether the wreck was caused by a hit and run or if alcohol may have been a factor.
The feeder road of the Crosby Freeway is shut down while the investigation goes on.
We're gathering details and will post anything new on abc13.com and our mobile news app. Reporter Foti Kallergis is on the scene and will report live on Eyewitness News at 6pm.