The Arizona Department of Public Safety says the Dallas-bound bus was heading east from Los Angeles when the accident occurred near Tonopah shortly before 2 a.m. Thursday.
The DPS says the bus crossed the highway median, but came to a stop before entering westbound traffic when other passengers restrained the man who had been pummeling the driver.
DPS spokesman Bart Graves says 25-year-old Maquel Donyel Morris of Los Angeles has been arrested and will be booked into jail on suspicion of numerous counts of endangerment, assault and aggravated assault.
Twenty-three people are injured, including three airlifted to hospitals for non-life threatening injuries.
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