Brandon Jackson, 18, is wanted for the killing of 37-year-old Ronalee McGuire.
It happened around 2:30am Thursday in an apartment detached from a home on Bobby Burns at Howton in northeast Houston.
The shooter fled with McGuire's girlfriend. Police had been looking for both of them.
Further investigation led police to charge Jackson with McGuire's murder.
Anyone with information on his whereabouts can call HPD Homicide at 713-308-3600 or Crime Stoppers at 713-222-TIPS.
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