The accident happened on the eastbound lanes of Memorial Drive near Shepherd around 2:30am.
Police say a woman who was allegedly speeding while trying to take an exit, lost control of her SUV and drove up a concrete embankment. She crashed into a barrier and her car burst into flames.
"Impacted with the guardrail at that point, a pretty catastrophic collision and we believe there was one occupant inside the vehicle and she was pronounced dead at the scene," said Sgt. Tim Trometer with the Houston Police Department.
The woman has not been identified.
The wreck had Memorial Drive closed in both directions for hours but the accident has since been cleared.