On eight possessions led by Manziel, Texas A&M (6-2, 3-2 Southeastern Conference) scored seven touchdowns. The only non-scoring drive run by the freshman nicknamed "Johnny Football" ended with a missed 48-yard field goal by Taylor Bertolet on the final play of the first half.
Manziel was in the game for only one series in the third quarter before watching the remainder of the rout from the sideline. He completed 16 of 23 passes for 230 yards and two touchdowns and had nine carries for 90 yards and three scores.
Auburn (1-7, 0-6), which has lost five straight, is off to its worst start since going 1-7 in 1952.
The Aggies gained 671 total yards, the most ever allowed by Auburn, in their first game at Jordan-Hare Stadium. Texas A&M led 42-7 at halftime and 49-7 after Manziel's final possession.
Manziel made an impressive recovery after three interceptions in a 24-19 loss to LSU last week.
Auburn coach Gene Chizik, looking for a spark for an offense that ranked among the bottom three in the nation in total yards and points per game, tried three quarterbacks.
Jonathan Wallace, a freshman, provided much-needed hope for the Tigers by completing 6 of 9 passes for 122 yards and two touchdowns. He threw 27-yard scoring passes to Emory Blake and C.J. Uzomah.
Wallace played behind starter Clint Moseley, who was pulled after only one series, and Kiehl Frazier, who completed 6 of 11 passes for 89 yards.
Jameill Showers and Matt Joeckel played behind Manziel. Showers led a scoring drive, capped by Trey Williams' 1-yard touchdown run, on his first possession.
Auburn's defense finally made a stop with Joeckel at quarterback, forcing Texas A&M's first punt. It drew sarcastic cheers from the fans with 38 seconds remaining in the third quarter.
Williams had 19 carries for 109 yards and a touchdown. Christine Michael had nine carries for 75 yards, including a 34-yard touchdown run in the second quarter. Ben Malena had seven carries for 63 yards, including a 7-yard touchdown run.
Tre Mason ran for 80 yards with a touchdown for Auburn.
The announced attendance was 85,119, but less than half of that crowd was still around midway through the third quarter.
