The latest crash happened in Shaanxi province just after dawn, the official Xinhua News Agency said. It did not immediately give any other details.
On Sunday, 36 people were burned to death when a double-decker bus rammed into a tanker loaded with high flammable methanol on another highway in Shaanxi, causing both vehicles to burst into flames.
Xinhua said 39 people were on the long-distance sleeper bus when it crashed, and that only three survived. It said the survivors were hospitalized, but didn't describe their condition.
In another accident on Sunday, Xinhua said 11 people were killed and another was seriously hurt when a van crashed into a truck in southwest China's Sichuan province. It did not give any other details
The tanker had just returned to the highway after a rest stop when it was apparently rear-ended by the bus at around 2:40 a.m. close to the city of Yan'an in Shaanxi, the official China News website said.
Xinhua photos showed the charred metal skeleton of the bus rammed up against the back of the tanker.
Road safety is a serious problem in China. According to Xinhua, poorly maintained roads and bad driving habits result in about 70,000 deaths and 300,000 injuries a year.