Barbara Faye O'Bryant was last seen around 7:45am Thursday near Veterans Memorial Drive at North Beltway 8.
She was wearing light-colored blue jeans, a gray long-sleeved shirt and white tennis shoes.
O'Bryant is a black with a medium-dark complexion, brown eyes and bronze hair. She is 5 feet 4 inches and weighs 115 pounds.
Anyone who has information on the possible whereabouts of this missing woman is urged to call the Harris County Sheriff's Office at 713-755-7427 or Texas EquuSearch at 281-309-9500.