It happened around 3am on Hoffman at Colfax.
Police said the driver was apparently speeding when he lost control of the car, jumped a ditch and slammed into a tree.
Four men were in the car. Three of them died and the fourth was taken to an area hospital in serious condition, police said.
Nearby resident Richy Garcia rushed outside when he heard the crash.
"It sounded like thunder, like a real loud boom," he said.
Garcia said he was shocked by what he saw.
"You can't even tell if it's a truck or a car," he said.
Two people were ejected and two were stuck inside the vehicle. Garcia called 911.
"They wanted me to give him CPR. I told them, 'the guy is dead, I cant give him CPR. And I don't know CPR,'" he said.
Investigators are looking into whether alcohol was a factor in the crash.