The wreck happened around 7:50pm on the North Freeway inbound at Patton.
Police say one vehicle hit another vehicle. According to police, the driver who appears to have caused the crash then fled the scene on foot.
Officials say that person may be badly injured, judging by the condition of his or her vehicle.
Traffic on the freeway was down to one lane after the accident. Lanes slowly re-opened as investigators cleared the scene.