It happened around 2am near the Belvedere Lounge on Uptown Park near Post Oak Boulevard.
Police say the driver told officers he just bought his Lamborghini a week ago and was still unfamiliar with how to use it properly.
The two pedestrians and a woman from one of the vehicles all went to an area hospital with minor injuries.
Police say the driver didn't appear to be under the influence of drugs or alcohol.
So far, he is not being charged since he stayed at the scene until authorities arrived.