The incident happened around 4:10am Wednesday at a convenience store in the 9600 block of Spring Green Boulevard, according to the Fort Bend County Sheriff's Office.
Surveillance video shows two men breaking into the store and prying the safe loose. They then loaded carried the safe out and loaded into a GM or Chevrolet SUV believed to be a Yukon or a Suburban. Authorities did not specify the contents of the safe.
A third suspect waited outside and acted as the getaway driver.
The first suspect is about 5 feet, 8 inches tall, has a heavy build and was wearing a long black mask that went down to his chest. He also was dressed in a blue, long-sleeve shirt, blue jeans and black tennis shoes.
The second suspect was about the same height, a heavy build and had the same kind of mask. He was wearing a black long-sleeve shirt, black pants with black tennis shoes with red bottoms.
The third suspect is described as 5 feet, 7 inches tall with a medium build. He was wearing a black T-shirt with blue jeans and had short black hair.
Fort Bend County Crime Stoppers has posted a reward of up to $5,000 for any information leading to the arrest and filing of charges on the suspects responsible for this crime. Anyone with information is asked to call the Fort Bend County Sheriff's Office at 281-341-4665 or Fort Bend County Crime Stoppers, Inc. at 281-342-TIPS (8477).