Police responded to a shooting call on Dairy Brook Drive near Brookwulf around 3:34am Saturday.
When officers arrived, they found three people shot in an alley.
Treaon Bush, 24, and Tremaine Burnett, 21, were already dead.
The third male victim was transported to an area hospital. At last check, that person's condition was unknown.
The motive has not yet been established.
Police said they are searching for three black male suspects in a newer-model, dark-colored BMW. Anyone with information is asked to call Crime Stoppers at 713-222-TIPS.