It happened around 8pm Saturday on Market at East Loop.
According to officials, the unidentified male driver ran the red light and then swerved into the median.
The vehicle flipped and the driver was partially ejected. He hit his head on the road and a guardrail, investigators said. He was pronounced dead at the scene.
Police say the vehicle smelled like alcohol and there were several beer bottles inside. The medical examiner will test his blood alcohol level.
No one else was injured.