Sharon Watkins, who surrendered to authorities three years ago, and her husband David Watkins, are charged with two counts of felony murder.
Investigators say in May 2003, the couple started a fire to a small part of their home to collect insurance money, but the fire spread out of control, trapping their 8-year-old daughter and a friend's teenage son inside.
The husband and wife were indicted in 2008.
David Watkins is also charged. He is scheduled to appear in court on Friday.