The red, white and black guitar is a replica of the original "Frankenstein" guitar that Van Halen used for more than 30 years. Van Halen constructed the "Frankenstein" guitar himself to suit his playing style.
Museum director Brent Glass says the guitar reflects Van Halen's innovation, talent and influence. It will be part of the museum's instrument collection as a more contemporary piece.
A museum spokeswoman says there are no current plans to put the guitar on public view.