Sesame Workshop, the New York-based nonprofit group behind the show, has created traveling exhibits before. But the partnership to be announced Thursday will be its first home at a museum.
Museum President and CEO Kathy Dwyer Southern says the "Sesame Street" characters will serve as virtual guides to the museum for children who visit. They'll also be included in a new Early Learners gallery and a planned international gallery.
The $182.6 million museum is slated to open in 2013.